Kamagra (Viagra) 100 mg Ajanta Pharma | TPT-0305

Brand:Ajanta Pharma
Product Code:TPT-0305
Availability:In Stock
  • 6.00€
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Description 


Kamagra-a drug for the treatment of erectile dysfunction. Sildenafil citrate is a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5). The physiological mechanism of penile erection involves the release of nitric oxide (NO) in the cavernous body during sexual stimulation.

Nitric oxide activates the enzyme guanylate cyclase, which leads to an increase in the level of cyclic guanosine monophosphate( cGMP), relaxation of the smooth muscles of the cavernous body and increased blood flow in the penis. In sexual arousal, the local release of NO under the influence of sildenafil leads to the suppression of PDE5 and an increase in the level of cGMP in the cavernous body, resulting in relaxation of smooth muscles and increased blood flow in the cavernous body. The use of sildenafil in the recommended doses is ineffective in the absence of sexual stimulation.

Kamagra has no effect on visual acuity, contrast sensitivity, intraocular pressure, or pupil diameter.

The drug at a dose of 100 mg does not affect the motor activity or morphology of spermatozoa when taken once.

Toxicological characteristics of the drug

The drug refers to practically non-toxic substances. It does not have a local irritant effect. It does not have teratogenic and embryotoxic effects, does not have immunotoxic and sensitizing effects.


Interaction


The effect of other drugs on Kamagra

The metabolism of sildenafil is mainly caused by cytochrome P450 (CYP), isoforms 3A4 (the main metabolic pathway) and 2C9 (the secondary metabolic pathway). Therefore, inhibitors of these isoenzymes may affect the clearance of sildenafil.

Cimetidine (800 mg), a non-specific CYP inhibitor, causes a 56 % increase in the plasma concentration of the drug when taken simultaneously with sildenafil (50 mg) in healthy volunteers.

Stronger CYP3A4 inhibitors, such as ketoconazole, itraconazole, or mibefradil, are thought to have a stronger effect. Data from clinical studies have shown a decrease in the clearance of sildenafil in patients when taken concomitantly with CYP3A4 inhibitors. It should be expected that simultaneous administration of CYP3A4 inducers, such as rifampicin, can reduce the level of sildenafil concentration in plasma.

A single dose of antacid (magnesium hydroxide/aluminum hydroxide) does not affect the bioavailability of sildenafil.

The pharmacokinetic data of patients in clinical trials did not show the effect of CYP2C9 inhibitors (such as butamide, warfarin), CYP2D6 inhibitors (such as selective serotonin reabsorption inhibitors, tricyclic antidepressants), thiazide and related diuretics, ACE inhibitors and calcium channel blockers on the pharmacokinetics of sildenafil. The AUC of the active metabolite, N-desmethylsildenafil, increases by 62 % under the influence of loop diuretics and potassium-sparing diuretics, and by 102 % when taken with non-specific beta-blockers. Such effects on the metabolite are not expected to have clinical consequences.

The effect of the drug on other drugs

In vitro studies: the drug is a weak inhibitor of cytochrome P450 isoforms 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 (IC50 " 150 mM). At the maximum plasma concentrations of the drug, which are approximately 1 mM after administration at the recommended doses, it is unlikely that the drug will affect the clearance of the substrates of these isoenzymes.

In vivo studies: no significant interactions were found when co-administered with tolbutamide (250 mg) or warfarin (40 mg), both of which are metabolized by CYP2C9.

Kamagra (50 mg) has no effect on increasing the bleeding time caused by aspirin (150 mg).

Kamagra (50 mg) does not increase the hypotensive effect of alcohol in healthy volunteers with average maximum blood alcohol levels of 0.08 %.

When the drug (100 mg) is taken simultaneously with amlodipine in hypertensive patients, the additional decrease in blood pressure in the supine position (on average, systolic by 8 mmHg; diastolic - by 7 mmHg) has a similar magnitude observed when taking only one drug in healthy volunteers.

The analysis of safety data showed no differences in the frequency of side effects in patients taking only Kamagra, and in patients taking the drug with antihypertensive agents.


Contraindications


● hypersensitivity to any component of the drug

● simultaneous administration of drugs that are donors of nitric oxide,

organic nitrates or nitrites in any form

● Heart failure

● unstable angina, myocardial

infarction, stroke, or life-threatening arrhythmias experienced in the last 6 months

●arterial hypertension (blood pressure (BP) "170/100 mmHg)

or arterial hypotension (BP" 90/50 mmHg)

●established congenital degenerative diseases of the retina

(retinitis pigmentosa, a congenital defect of retinal phosphodiesterases)

●Children and adolescents under 18 years of age

●Not intended for use in women


Side Effects 

● headache, migraine

●Dizziness

● visual disturbances (moderate and short-term, mainly

expressed by a violation of color perception, as well as increased

sensitivity to light or "blurred" vision)

● a rush of blood to the face

● nasal congestion, flu-like syndrome

● Dyspepsia

Infrequently

●Mydriasis, conjunctivitis, photophobia, eye pain, eye hemorrhages,

cataracts

● Tinnitus, ear pain

● shortness of breath, cough, laryngitis, pharyngitis, sinusitis, bronchitis, bronchial asthma

● Palpitations, tachycardia

Method of application 

The drug is taken orally; swallowing the tablet whole and drinking a small amount of water. When taken on an empty stomach, the effect is faster. The drug is taken about 1 hour before sexual activity.

Apply strictly under the supervision of a doctor.

For most patients, the recommended dose is 50 mg.

Taking into account the effectiveness and tolerability, the maximum single dose can be increased to 100 mg or reduced to 25 mg.

The drug should be taken no more than once a day.

Active substance Viagra
Active ingredient, mg 100
Release form Bustina, Pills
Manufacturer Ajanta Pharma
Packing Sachet, Packing (7 Sachet), Blister (4 pills)
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