Roas 10 mg Pharmacom Labs | TPT-0302

Isotretinoin, also known as 13-cis-retinoic acid, is an oral pharmaceutical drug that is mainly used to treat acne. Occasionally, it is also used to prevent certain types of skin cancer, treat other types of cancer. It is used to treat Harlequin-type ichthyosis, a commonly fatal skin disease, and lamellar ichthyosis.

It is a retinoid, which means that it is bound to vitamin A and is naturally found in small amounts in the body.

Isotretinoin increases the production of neutrophil gelatinase-bound lipocalin (NGAL) in the skin, which has been shown to reduce sebum production, causing apoptosis in sebaceous gland cells, showing an antimicrobial effect on Propionibacterium acnes. The drug reduces the size and removal of sebum from the sebaceous glands. Isotretinoin is the only available acne medication that affects all four major pathogenic processes in acne, which distinguishes it from alternative treatments (such as antibiotics) and explains its effectiveness in severe cases with a nodular cyst.

Oral isotretinoin is best absorbed when taken with a high-fat diet, as it has a high lipophilicity. The effectiveness of isotretinoin is doubled when taken after a high-fat meal compared to taking without a meal. Due to the molecular ratio of isotretinoin to vitamin A, it should not be taken with vitamin A supplements due to the risk of toxicity due to cumulative overdose.

Isotretinoin is the most effective acne treatment on the market. The most common side effects are a temporary exacerbation of acne (lasting 2-3 weeks), dry lips, dry and fragile skin, and an increased tendency to sunburn. Unusual and rare side effects include: muscle aches and headaches.

Isotretinoin is known to cause birth defects due to intrauterine exposure due to the close similarity of the molecule to retinoic acid, a natural derivative of vitamin A that controls normal embryonic development. The risk of birth defects in infants exposed to intrauterine exposure to the drug is about 20-35%, and approximately 30-60% of children exposed to prenatal exposure to isotretinoin have neurocognitive disorders. Because of this, there is strict control over the administration of isotretinoin to women who may become pregnant, and women who become pregnant while taking isotretinoin are strongly advised to terminate the pregnancy.